Fig. 1                                                         Fig. 2

Trabecular Titanium^TM demonstrates to have an osteoinductive behavior. Human adipose stem cells (hASCs) grown on TT are able to adhere, proliferate and differentiate into osteoblastlike phenotype thus producing a mineralized extracellular bone matrix¹ (Figure 1). The quality and quantity of the extracellular matrix are important to determine the osseointegration of a material and therefore the resistance and the survivorship of an implant. If compared to other biocompatible scaffolds of different material and structure, the amount of bone matrixproteins  produced by hASCs differentiated in osteoblast phenotype on TT was significantly higher (Figure 2). These results lead to the conclusion that not only the material but also the structure significantly affect cell proliferation². 

[1] Gastaldi G, Asti A, Scaffi no MF, Visai L, Saino E, Cometa AM, Benazzo F. Human adipose-derived stem cells (hASCs) proliferate and differentiate in osteoblast-like cells on trabecular titanium scaffolds. J Biomed Mater Res A. 2010 Sep 1; 94(3): 790-9.

[2] Asti A, Gastaldi G, Dorati R, Saino E, Conti B, Visai L, Benazzo F. Stem cells grown in osteogenic medium on PLGA, PLGA/HA, and Titanium scaffolds for surgical applications. Bioinorg Chem Appl. 2010: 831031.